The Beckman Coulter DTX 880 is a spectrophotometer for the UV-Visible wavelength range that provides the operator a great deal of flexibility for sample analysis. Accepting a range of microplates from 6- to 384-well plates means operators have a fair amount of flexibility in assay development. Increasing flexibility in analysis are the seven detection modes provided by the DTX 880. Included are seven detection modes ranging from fluorescence, glow luminescence, and absorbance. Fluorescence modes include fluorescence intensity (top and bottom reads), time-resolved fluorescence, and fluorescence polarization. Absorbance modes include detection for both UV and visible spectra. Reading modes can be programmed for endpoint, kinetic, multiple wavelengths, linear scan and area scan. This variety of reading mode options is what makes this multimode spectrophotometer such a flexible option for research laboratories.
With this instrument, laboratories are given two viable options for fast and sensitive readings. This multimode detector is capable of both stand-alone operation and integration with robotic systems. The integration of such systems is facilitated by a plate access door that is wide enough to allow for versatile positioning of robotic ports. Regardless of integration, speed is provided with results given in times anywhere between mere seconds for Fluorescence Intensity (Top Read) and a few minutes for Time-Resolved Fluorescence. Speed does not come at a loss in sensitivity, which is completely adjustable by the user who has the ability to adjust the read heights of the detector. All aspects of detection and programming are easily controlled via computer-based software designed for the instrument.
Given the flexibility and sensitivity of the DTX 880, there are a wide range of applications in the field of systems biology. This includes applications in genomics, proteomics, cell-based research, and assay development. The instrument is valuable in experiments involving ELISA assays, genotyping, protein quantitation, and many more.