Widely used in chemistry labs and medical research, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available for determining the structure of organic compounds. It is based on the physical phenomenon of nuclear magnetic resonance, in which atomic nuclei behave like small magnets and align themselves with an external magnetic field.
The following are some general applications of NMR spectroscopy:
- Solution structure: NMR spectroscopy is the only method for atomic-resolution structure determination of biomacromolecules in aqueous solutions under near physiological conditions or membrane mimeric environments
- Molecular dynamics: NMR spectroscopy is the most powerful technique for quantifying motional properties of biomacromolecules
- Protein folding: NMR spectroscopy is a powerful tool for determining the residual structures of unfolded proteins and the structures of folding intermediates
- Ionization state: NMR spectroscopy is used for determining the chemical properties of functional groups in biomacromolecules, such as the ionization states of ionizable groups at the active sites of enzymes
- Weak intermolecular interactions: NMR spectroscopy enables the study of weak functional interactions between macrobiomolecules (e.g., those with dissociation constants in the micromolar to millimolar range), which is not possible with other technologies
- Protein hydration: NMR spectroscopy is a powerful tool for the detection of interior water and its interaction with biomacromolecules
- Hydrogen bonding: NMR spectroscopy is a unique technique for the DIRECT detection of hydrogen bonding interactions
- Drug screening and design: NMR spectroscopy is particularly useful for identifying drug leads and determining the conformations of the compounds bound to enzymes, receptors, and other proteins
- Native membrane protein: solid state NMR has the potential for determining atomic-resolution structures of domains of membrane proteins in their native membrane environments, including those with bound ligands
- Chemical analysis: NMR spectroscopy is used for chemical identification and conformational analysis of chemicals, whether synthetic or natural
- Material science: NMR spectroscopy is used as a tool in the research of polymer chemistry and physics
If you have a need for a used NMR, give us a call at 858-550-0800 x201. We have a Varian Mercury 300 system in stock. The system comes with two probes, the Mercury console, Sun station with VNMR 6.1C. It has an Oxford magnet with 54mm bore and is ready to ship today.